Curr Biol：分散注意力可有效缓解肿胀

近日，刊登在国际著名杂志Cell的子刊Current Biology上的一篇分析报告指出，利用心理干扰（分心）的方法可以使得痛楚减低，然而这种痛楚大大降低减低的波动不一定展示出在头部。这项分析挖掘出是基于用到分光镜的胰脏机能性磁共振成像核心技术（fMRI核心技术），对人们由于加热导致的痛楚程度进行分析，分析概述，心理干扰确实可以在帝都痛楚处理早期抑制痛楚波形的传入。来自法兰克福-埃敏多夫学院学院的分析成果Christian Sprenger对此，这种现象并众所周知是一种心理现象，而是一种活跃的神经机制，可以降低从脑上升至小脑高级区域的痛楚波形。

这种波动牵涉到到了诱导的类有机物，这种有机物消除自小脑，在减低痛楚的过程中扮演关键性剧情。分析人员让参与者分别完成一个简单或者一个都能的记忆性特殊任务，需要他们记起信件的文字内容，同时给参与者胳膊上施以加热。进行都能特殊任务的参与者越发心烦意乱时，他们会觉得相当大的痛楚，通过fMRI核心技术看出出这些参与者的脑区域活性越发来得低，fMRI不一定一定是用来测定小脑活性的转变。

Sprenger和他的同事然后每一次了实验，这次他们获取参与者一种用药-钠洛酮（抗休克的理想用药，可以阻拦类用药的波动）或者平常的东石流进，得出结论，相比只流进平常东石的参与者，用到类用药拮抗剂的参与者由于注意力充分利用，导致的痛楚大大降低降低了40%，因此说明了诱导的扮演关键性抑制作用。

分析成果的挖掘出概述了心理过程可以深入地转变人们的痛楚经历，并且对于医学也有极其关键性的意义。分析成果对此，我们的分析挖掘出给痛楚疾病外科手术提供者了本质行为外科手术的方法。（生物谷：T.Shen程式码）

doi:10.1016/j.cub.2012.04.006PMC:PMID:

Attention Modulates Spinal Cord Responses to Pain

Christian Sprenger1, , , Falk Eippert1, Jürgen Finsterbusch1, Ulrike Bingel1, 2, Michael Rose1, Christian Büchel1

Reduced pain perception while being distracted from pain is an everyday example of how cognitive processes can interfere with pain perception [ [1], [2], [3], [4] and [5]]. Previous neuroimaging studies showed distraction-related modulations of pain-driven activations in various cortical and subcortical brain regions [ [6], [7], [8], [9], [10] and [11]], but the precise neuronal mechanism underlying this phenomenon is unclear. Using high-resolution functional magnetic resonance imaging of the human cervical spinal cord in combination with thermal pain stimulation and a well-established working memory task [12], we demonstrate that this phenomenon relies on an inhibition of incoming pain signals in the spinal cord. Neuronal responses to painful stimulation in the dorsal horn of the corresponding spinal segment were significantly reduced under high working memory load compared to low working memory load. At the individual level, reductions of neuronal responses in the spinal cord predicted behioral pain reductions. In a subsequent behioral experiment, using the opioid antagonist naloxone in a double-blind crossover design with the same paradigm, we demonstrate a substantial contribution of endogenous opioids to this mechanism. Taken together, our results show that the reduced pain experience during mental distraction is related to a spinal process and involves opioid neurotransmission.